Manipulating intracellular sphingolipid levels


Project description
The artificial non-invasive manipulation of intracellular events is essential to dissect the complicated signaling networks that drive cell function. In this project, novel methods to alter ceramide and sphingolipid levels will be developed and applied to a variety of cellular applications within the consortium. Specifically, photoactivatable derivatives of several lipids will be synthesized. In addition, we will develop methods based on chemical dimerizers to modulate lipid levels by activating lipid-metabolizing enzymes.   

Further reading
Putyrski & Schultz, Chemistry & Biology 18, 1126-1133, 2011
Mentel et al., Angewandte Chemie 50, 3811-3814, 2011
Subramanian et al., Nature Chemical Biology 6, 324-326, 2010
Laketa et al., Chemistry & Biology 16, 1190-1196, 2009
Host institute
European Molecular Biology Laboratory (EMBL), Germany
Cell Biology & Biophysics Unit
Supervisor: Dr. Carsten Schultz
Phone: +49 (0)6221 387 210

The EMBL is the leading European institute for molecular biology. It provides a strictly international environment and hosts strongly interdisciplinary groups including those that focus on physics, mathematics and chemistry.

•    We are looking for an ambitious and interactive individual with MSc degree or diploma in organic chemistry, molecular cell biology or chemical biology. A solid background in in organic chemistry methods is mandatory. Experience in lipid chemistry and assay development is an advantage.
•    The candidate will be part of a multidisciplinary team of chemists, geneticists, biophysicists, biochemists and cancer biologists. Good communication skills and mobility are essential.
•    Proactive participation in SPHINGONET’s research & training program is expected through presentations and critical thinking at internal scientific forums, requiring excellent English presentation and writing skills. The ability to work in a team is a must.
•    Candidates must fulfill the eligibility criteria for Marie Curie Initial Training Networks (FP7).
•    Candidates should submit the complete application package.
•    Suitable candidates will be invited for an interview by the supervisor of the project.

•    PhD student for 3 years. Extension of the contract to 4 years is possible.
•    Full-time (42 hours/week)